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Graduate student Marshall Plumlee's career came to a close Thursday after blossoming in his final season in Durham.
Grayson Allen hit two of his six attempts from beyond the arc and was not able to consistently get to the free-throw line in the second half to help keep Duke within striking distance.
Oregon ran Duke's shooters off the 3-point line, keeping Matt Jones and the Blue Devils under wraps for most of the night.
Luke Kennard was the lone Blue Devil guard to shoot better than 50 percent from the field, but the freshman was just 1-of-5 from beyond the arc.
Sophomore Grayson Allen finished with 15 points, but had just three in the first half and shot 4-of-13 from the field.
Oregon's length and athleticism frustrated the Blue Devils all night as the top-seeded Ducks knocked the Blue Devils out of the NCAA tournament.
Chase Jeter and the Blue Devils watched their season come to a halt Thursday night in Anaheim, Calif.
Duke head coach Mike Krzyzewski touted Oregon's ability to defend the perimeter while also turning away Blue Devil slashers at the rim.
Marshall Plumlee's Duke career came to an end Thursday with six points and five rebounds in the Sweet 16 loss to Oregon.