With the comeback bid falling short, Duke has now dropped three one-goal contests to top-10 teams.
Ashlyn McGovern started Virginia’s run of six straight goals to open the game.
Duke controlled the pace throughout the game, and Charlotte North led the way with a game-high five goals, including her 100th marker in Duke blue.
After scoring 59 times in their first three contests, the Blue Devils struggled to get going offensively.
Virginia Tech (2-2, 0-0) has struggled against two ranked opponents to start the season, getting outscored 31-14 in its two losses, both at home.
With two freshmen joining the mix for a team that reached the semifinals of the NCAA Tournament last season, Duke is hoping to iron out its rotation.
Although Duke's 2018 record might not indicate stellar play, the Blue Devils have consistently gotten outstanding performances their quarterback.