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With Jones leading the way, the Blue Devils forced 18 Michigan State turnovers—including eight in the second half.
Amile Jefferson had his fourth double-double in five games Tuesday with 17 points and 13 rebounds.
The Blue Devils broke a 48-48 tie with an 11-0 spurt to take control despite only utilizing a six-man rotation against a deep Michigan State squad.
Grayson Allen heated up as the game went along Tuesday and finished with 24 points and five of Duke's seven made 3-pointers.
Michigan State head coach Tom Izzo had conversations throughout the game with Miles Bridges as the Spartan superstar struggled to get on track.
Junior Grayson Allen went just 2-of-10 in the first half but made three quick hoops to start the second.
Freshman Frank Jackson keyed the Blue Devils' game-defining second-half run Tuesday with back-to-back layups.