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Harry Giles had his shining moment Friday, with a career-high four blocks and huge alley-oop to send the Barclays Center crowd to its feet.
Frank Jackson scored all 15 of his points after halftime, including the go-ahead 3-pointer with about nine minutes left.
Quentin Snider had 15 points Thursday but went just 1-of-6 from long range, settling for a few 3-pointers in the second half that stalled Louisville's offense against the Blue Devils' zone.
First-team All-ACC guard Donovan Mitchell shot just 3-of-14 against the Blue Devils, with four fouls also limiting him on the defensive end late in the game.
Matt Jones and the Blue Devils fought hard inside in their zone defense to turn Thursday's game around.
Jayson Tatum poured in 25 points on 9-of-15 shooting to lead the Blue Devils past Louisville in the ACC tournament quarterfinals.
Freshman Jayson Tatum had 25 points on 9-of-15 shooting, using his quickness to attack the rim against bigger players and getting loose in transition.
Jayson Tatum was in attack mode all game Thursday, pouring in 25 points to shake off a disappointing regular-season performance against Louisville in January.
After the Blue Devils switched to their zone defense, Louisville's aggressiveness attacking the basket seemed to disappear.
Although freshman Frank Jackson picked up three first-half fouls, Grayson Allen stepped up to give the Blue Devils a spark off the bench.