In the midst of a 2-9 skid, Duke will face Charlotte in a nonconference matchup Tuesday night at Robert and Mariam Hayes Stadium. First pitch is scheduled for 6 p.m.
The 49ers (17-21) lost to the Blue Devils (15-26) 4-1 last season, the first matchup between the teams since 1987.
Duke freshman right-hander Andrew Istler will make his first collegiate start on the mound against Charlotte right-hander Tyler Barnette.
Istler has made 17 appearances for the Blue Devils out of the bullpen this season and sports a 2-3 record with a 4.81 ERA.
He has also started 25 games for the Blue Devils in the outfield, hitting .284 with two doubles and eight RBI.
Barnette has a 1-2 record in his seven starts and holds an ERA of 4.32. In his last start, Barnette was roughed up by Dayton, giving up four earned runs in just two innings of work.
Charlotte has relied on its bats all season, boasting a lineup with five starters hitting over .300. Outfielder Shane Brown leads the team with an on-base percentage of .435, and first baseman Corbin Shive has a .318 batting average with 13 extra-base hits.